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KMID : 0360220110520060658
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Journal of the Korean Ophthalmological Society
2011 Volume.52 No. 6 p.658 ~ p.664
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Analysis of CCL5 Concentration in Tears of Dry Eye Patients
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Choi Won
Lee Seung-Hyun
Yoon Kyung-Chul
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Abstract
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Purpose: To investigate the expression of CCL5/RANTES (regulated upon activation, normal T cell expressed and secreted) in the tears of dry eye patients.
Methods: Forty patients with dry eye (15 Sjogren’s and 25 non-Sjogren’s syndrome patients) and ten control subjects were recruited for the present study. The concentration of RANTES in tears was measured using an enzyme-linked immunosorbent assay. The correlations between RANTES level, tear film and ocular surface parameters, including tear film break-up time, basal tear secretion, tear clearance rate, corneal sensation, keratoepitheliopathy, and conjunctival goblet cell density, were analyzed in patients with dry eye syndrome.
Results: The concentrations of RANTES were 435.46 ± 104.45 pg/ml in Sjogren’s syndrome patients, 257.42 ± 46.72 pg/ml in non-Sjogren’s syndrome patients, and 97.53 ± 29.15 pg/ml in the control patients (p < 0.01). The levels correlated significantly with basal tear secretion, tear clearance rate, keratoepitheliopathy, and goblet cell density (p < 0.05).
Conclusions: CCL5/RANTES level increases in the tears of dry eye patients and correlates with various tear film and ocular surface parameters.
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KEYWORD
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CCL5/RANTES, Dry eye, Ocular surface, Sjogren’s syndrome, Tear film
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